In the first instalment of Reason at Large Craig Biddle is dealing with Kant's school of altruist ethics and the “is-ought dichotomy”, also known as Hume's Law. Both fallacies are causing a blind spot for objective morality, which on that basis they continue to deny. Just because your intellectual tools are insufficient to figure it out, that doesn't mean it doesn't exist!
Hume's law states, it is not possible to derive moral principles from Reality, from what Is.
Biddle explains in the video the fallacy at the heart of Liberalism, known as Hume's Law. It explains why Liberalism started as a reasonable enough premise until it outsourced all matters of morality to religion. And since the sacred has no business with the secular, a wall was erected that leads Liberalism in the final stages to a position of Nihilism. Which is where we are today.